Since coming home from the animal hospital Ruff has been dealing with a recurrence of deep pyoderma like he had once before 8 years ago. This time the Vet started him on a long term regimen of 3000mg of Cephalexin (2 x 500mg three times a day) for 8 weeks but when it showed no sign of improvement he sent some cultures out to a lab for testing and found Ruff's infection was resistant to the Cephalexin so now Ruff is taking two new antibiotics 3000mg of Amoxicillin (3 x 500mg twice a day) and 1600mg of Sulfamethoxazole-TMP (1 x 800mg twice a day) I got the prescriptions filled at the local pharmacy instead of at the Vets office to save some money.
The new antibiotic does appear to be helping. The dried up pus scabs have broken loose and I am bathing his head with Dial antibiotic hand soap. I am surprised at the progress because the available info I found said Amoxicillin would be ineffective.
Amoxicillin, penicillin, and tetracyline are inappropriate choices for treating superficial or deep pyodermas because they are ineffective in 90% of these cases.The antibiotic of choice has always been Cephalexin yet the cultures our Vet sent out to the lab said the current strain of bacterial infection that Ruff had was resistant to this drug. The lab report recommended a few of the drugs most responsive to treatment and the Amoxicillin was the most affordable on the list.
My initial research 8 years ago was due to an outbreak of Deep Pyoderma that the Vet was unable to control. Back then the Vet would prescribe a moderate dose of Cephalexin for 10 days which would clear it up but then two weeks later Ruff came down with another much larger infection. I found a published paper ( https://actavet.vfu.cz/76/3/0469/ ) in the Journal of the University of Veterinary and Pharmaceutical Sciences in Brno, Czech Republic "Therapy of Canine Deep Pyoderma with Cephalexins and Immunomodulators" that described in detail an 11-week long treatment of high doses of Cephalexin. I showed it to my Vet and he wrote out a prescription for 3 months supply and I filled it at WalMart. It did the job and Ruff never had a repeat until after he had the radiation treatment.
There is still no signs of improvement in Ruff's eyesight but he learned to walk slowly around the house to avoid bumping into the furniture. He has always managed to find his way into the kitchen at dinner time when he hears me opening up the cans of dog food.